Vaccine is a kind of biological product, which is prepared by biotechnology and is used to prevent and treat human diseases. The filtration technology is widely used at different stages of the vaccine process. S&P provides a comprehensive downstream purification and separation solution for mcab clients, package solutions from clarification filtration, ultrafiltration, virus removal to final sterilization filtration.

1 clarification:

The main objective of the clarification process is to remove cellular and granular impurities in the cell harvest fluid. The impurities are removed by the traditional process of two-stage centrifugation. At present, deep filtration is widely used in clarifying process steps.

Deep-bed filtration is the use of porous media from the mobile phase interception of solid particles rather than the surface interception, and the general medium surface with a positive charge, can be through electrostatic adsorption to intercept impurity particles.

Applicable products: SaiClear P series and S series clarifier

Plasmid clarification: 0.45-5μm PP filter, for details →

SaiClear P series clarification filters, learn more →

2 ultrafiltration:

The main purpose of ultrafiltration is to concentrate the sample and transfer the solution into the preparation buffer. In addition to the conventional flux, the shear resistance of the target protein should be concerned.

Applicable products: Teomax PES D ultrafiltration membrane package, understand the details →

3 sterilization and filtration:

Filtration is a process that removes microorganisms from a liquid stream without adversely affecting the quality of the product. The bacteria in liquid or air clocks are removed by physical retention filtration to achieve

Sterile purpose. The class of the sterilizing filter has been controversial, mainly because of the lack of consistency among manufacturers in measuring aperture. Because of the limitation of defining filter according to pore size, the definition of filter is based on bacteria retention capacity. PDA TR26 states that, under specified conditions, interception is per square centimeter within the effective filter surface area

B. Diminuta ATCC 19146 capacity of 107 filters are defined as bactericidal grade filters.

Applicable products: sterilization and filtration of terminal feed: SaiPress 0.22 μm for details →

Medium filtration: SaiPress 0.45 + 0.22 μm for details →

Buffer filtration and pre-column protection: Polysai pre-filter, SaiPress 0.22 μm for details →

Gas Filter & Respirator: Filgiant 0.22 μm for details →